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Question of the Day


What is end of dose failure pain?

End of dose failure pain is breakthrough pain that develops because the dosing of the around-the-clock analgesic medication is scheduled too far apart in time. Pain emerges prior to the time that the next scheduled dose of analgesic medication is due. Although this may be difficult to predict for any given patient at the onset of therapy, patterns of pain can be detected. It is important to monitor pain symptoms in relation to the dosing schedule. Once a pattern of pain is detected, pain can be prevented by using sustained-release agents and changing dosing intervals as needed.